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Statins Side Effects - Diabetes, Rhabdomyolysis & Cardiomyopathy

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Statins are a class of drugs that lower cholesterol levels in the blood. Use of statins has been linked to statin side effects including an increased risk of cardiomyopathy and diabetes. The high-potency and best-selling statins, namely Lipitor, Crestor and Zocor, have been found to increase statin diabetes risk by up to 15 percent. Additionally, a link between statins and rhabdomyolysis has been reported.

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Statin Drugs

Statins lower a patient's blood cholesterol by reducing the amount of cholesterol the liver produces. By lowering the amount of cholesterol in the blood, statins are used to treat and prevent atherosclerosis, which can cause chest pain, heart attacks and strokes.

Common side effects of statins include headache, nausea, vomiting, constipation, diarrhea, rash, weakness and muscle pain.


Drugs in the Statin Class

Altoprev(lovastatin extended-release)
Crestor (rosuvastatin)
Lescol (fluvastatin)
Lipitor (atorvastatin)
Mevacor (lovastatin)
Pravachol (pravastatin)
Zocor (simvastatin).

Drugs that Combine a Statin with another drug

Simcor (a combination of simvastatin and niacin)
Vytorin (a combination of simvastatin and ezetimibe)

Statins and the FDA

On February 28, 2012, the FDA announced that use of statins was associated with an increased risk of diabetes mellitus. Although the FDA said the risk is small, some critics argue that studies investigated by the FDA included statins that were not as potent as others. For every 167 people taking Crestor, for example, one person developed diabetes. That's compared with one in every 255 patients treated with a statin overall.

In March 2012, the FDA announced a label change to alert patients to the risk of side effects and possible drug interactions linked to statin use. According to the FDA, there have been reports of muscle injury when statins are used with fibrates (cholesterol-lowering drugs), niacin (in large doses), Ranexa (used to treat angina) or Colchicine (used to treat gout).

The FDA also noted that there were reports of serious liver problems in patients who use statins. Although those reports are rare, the condition is serious. Symptoms of liver problems include tiredness or weakness, loss of appetite, upper abdominal pain, and dark-colored urine. Some patients have also experienced an increase in blood sugar levels.

In October 2012, the FDA announced a change to the warning label of drugs in the statin class. That change was made to alert patients to the risk of immune-mediated necrotizing myopathy (IMNM), an autoimmune myopathy, a rare condition that is associated with statin use. Symptoms of IMNM include proximal muscle weakness and increased serum creatine kinase, both of which can continue after statin therapy has been discontinued.

The FDA has not removed statins from the market, saying it believes the benefits of statin drugs continue to outweigh the risks.


Statin Cardiomyopathy Risk

Some statins have reportedly been linked to an increased risk of cardiomyopathy, a serious weakening of the heart muscle or a change in the structure of the heart muscle. Cardiomyopathy is associated with the heart's inability to pump blood adequately and other problems related to the function of the heart.

Statin Diabetes Risk & Statin Diabetes Research

April 2015: A study of healthy adults conducted by Veterans Affairs researchers and published in the Journal of General Internal Medicinefound that Lipitor, Zocor and Crestor may significantly increase the risk of developing diabetes. Researchers reviewed data involving 26,000 beneficiaries of the Tricare military health system. This study was unique in that it involved people who had no history of diabetes, heart disease or severe chronic diseases.

March 2015: The medical journal Diabetologia reported that a study conducted by researchers in Finland found that use of the popular cholesterol drugs like Lipitor and Zocor may increase the risk of Type 2 diabetes. More than 9,000 patients ages 45-73 were followed over a period of six years. Researchers found that the risk of Type 2 diabetes was increased by about 46 percent for those taking Lipitor and Zocor. The findings were dose-dependent, meaning that the larger the dose, the more likely a diabetes diagnosis. Further, statin treatment reduced sensitivity to insulin and reduced insulin secretion over time.

September 2014: Research published in The Lancet found that the enzyme statins designed to control cholesterol are also tied to a number of factors affecting blood sugar.

May 2014: A Canadian study published in BMJ (5/29/14) concluded that patients who are prescribed strong statins like Crestor, Zocor and Lipitor are looking at a 15 percent increased risk for diabetes within two years, when compared against patients taking statins that were considered low in potency.

February 2014: A UK study published in the European Society of Cardiology found that 3 percent of those taking statins were later diagnosed with diabetes, compared to only 2.4 percent who were given a placebo.

2006: The JUPITER study (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) found that in certain patients, the risk for newly developed diabetes increased 25 percent in patients who used Crestor (a statin drug) over those who were given a placebo. Meanwhile, a meta-analysis of six statin studies showed the risk of new-onset diabetes increased by about 13 percent when patients were given a statin.

Statin Lawsuits

More than 2,300 Lipitor lawsuits have been filed in the District of South Carolina on behalf of individuals who allegedly developed Type 2 diabetes due to their use of the statin, according to court documents. The lawsuits claim that Pfizer knew or should have known about risks associated with their medication for years, but withheld diabetes warnings from the medical community and the public to avoid a negative impact on sales and growth of the world's best-selling ever medication.

Crestor lawsuits have been filed against AstraZeneca on behalf of former users of the statin who were diagnosed with Type 2 diabetes. Many Crestor cases are currently pending in California state court.

Several Lipitor lawsuits filed in April 2013 are seeking to consolidate all similar federal actions in the U.S. District of South Carolina. After speaking with a Lipitor diabetes lawyer in March 2013, a South Carolina woman filed a Personal Injury and Product Liability lawsuit against Pfizer. The lawsuit claims that Pfizer promoted and marketed Lipitor as safe and effective and that Pfizer did not adequately disclose this risk to its consumers. Plaintiff Evalina Smalls claims that prior to taking Lipitor she lived a healthy and proactive lifestyle. She was not overweight and had a healthy diet. But she was diagnosed with Type 2 diabetes after taking Lipitor for about ten years to decrease her risk of heart disease. (Case Number 2:2013cv00796)

See Lipitor Litigation up to October 2013

See Crestor litigation up to October 2013

Lawsuits filed by US women diagnosed with Type 2 diabetes increased from 56 to almost 1,000 in a period of five months, Reuters reported in August 2014. The diabetes lawsuits began shortly after the FDA in 2012 warned that statins, including Lipitor and Crestor, were linked to incidents of memory loss and a "small increased risk" of diabetes. Women face a higher risk than men of developing diabetes from using Lipitor, and gain fewer benefits, according to plaintiffs' lawyers.

Statin Side Effects Legal Help

If you or a family member have taken a Statin and have experienced any side effects, please click the link below to have your Statin Side Effect claim submitted to a Drug and Medical Device attorney for further review.
Last updated on Sep-10-15

STATIN LAWSUITS

Vytorin alleged risk of heart attack and liver damage.

Zetia Merck and Shering-Plough have conducted unpublished tests that raise questions about risks of heart attack for Zetia users.

Lipitor Diabetes Lawsuit Canada Attorneys are now looking into the possibility of filing personal injury lawsuits in Canada.

Simvastatin and Amiodarone alleged risk of Rhabdomyolysis when drugs used together.

Zetia Merck and Shering-Plough have conducted unpublished tests that raise questions about risks of heart attack for Zetia users.

Zocor Warning Issued by FDA

Crestor Side Effects

STATIN LEGAL ARTICLES AND INTERVIEWS

Concern Over Crestor Side Effects Is Old News
Concern Over Crestor Side Effects Is Old News Washington, DC: AstraZeneca, the manufacturer of Crestor, recently released its third-quarter (Q3) results for 2015 during which the company referenced various patent and personal injury lawsuits for the benefit of investors and analysts concerned, as they are, about all aspects of doing business. And a Crestor lawsuit, for a pharmaceutical firm, is simply part of doing business. However, various Crestor side effects have not only been fueling lawsuits, but have also been raising the ire of health advocates for some time [READ MORE]

Crestor Lawsuits Still Percolating
Crestor Lawsuits Still Percolating Los Angeles, CA Not that Americans could be accused of popping any medication like candy. But there are times when consumers have become so desensitized to medications, that popping a pill such as an aspirin or a statin to rein in bad cholesterol is rarely given a second thought. However, with statins, and specifically Crestor, a second thought might be warranted with regard to Crestor side effects [READ MORE]

Are Statins Linked to Aggression?
Are Statins Linked to Aggression? Boston, MA When people start taking Crestor, they likely watch for some of the reported Crestor side effects that affect them physically. Not many people think to watch for emotional side effects linked to medications. But a recently published study suggests statins may be linked to increased aggression in women [READ MORE]




READER COMMENTS

Posted by
Mari
on
I try Simvastatin and gave me cramps doctor change to Lovastatin and same results then he wants me to try Zetia and boy my feet look like cucumbers and cant walk finally I am now in Pravastatin and my thighs hurt and my legs hurt so much ..........If these meds are not safe why doctors keep using them in patients ? I am 71 and sometimes I am scared of this statins that I feel like not taking them anymore !

Posted by
Peter Carlos Estep
on
I had a reaction to lovastatin in 2005 and have been in constant pain since. There was no proof of the cause but it happened almost overnight after taking it for a few months so my guess would have to be the drug.
My doctor had just purchased the clinic from my previous doctor who had just retired and she directed me to stop taking them.
So I have endured the pain mainly in the back, hips, and iliotibial band. There were number of other odd reactions - fatigue, cognitive problems, rashes (which can happen with some forms of myositis).
The pain was a real myriad of sensations -
In May of 2015 on the advice of my doctor I started going to a myofascial massage therapist and have been getting relief in increments with an end in sight to all this. It is a very
aggressive working lose of the fascia - what we have found in me was a lot scar tissue, dried blood and lumps of fat that she has worked out of me. That is the only therapy I have tried that has worked for me but after reading some of these entries I think there are a number of folks that could benefit from it.
One vent I have about it is the way the medical community lack of addressing this, the research and addressing this almost non-existent from what I can tell, so we are on our own.
Any one is welcome to contact me if they have questions and good luck to all!

Posted by
Troy
on
I was on Lipitor 80mg for 3 years then Crestor 80mg for 2 years, then Zocor 80mg for about 14 years. I finally went to the doctor because I couldn't even climb one flight of stairs, my blood sugar was high borderline diabetic, my blood pressure was high, I have constant muscle pain in my legs and arms, and I have little strength and am always exhausted. My muscles don't heal like they should. I would like to join a class action lawsuit. I'm only 54 and am struggling to keep a job.

Posted by
erin b magner
on
I was put on Lovastatin in2012 after a neck injury did not allow me my normal active lifestyle. i stayed on them because at some point it was determined i needed surgery and I did not want to make anything worse. Because my injury caused nerves to be irritated i thought that was the leg pain almost constant, weakness ,pain in the Achillies tendon and the tendons around my knees. i could barely climb stairs or stand without pain and any exercise made the problem worse and my muscles will quiver and i can hardly lift my legs to walk. However long after i recovered and healed from the neck fusion i still am in horrible pain.
The week before my daughters wedding i was there helping her and had to stop many times to go cry in a pillow because of the leg pain.Many times the ibprophen didn't help or barely dulled the pain. Also because of the tendon problems i am still very unstable feeling like a marionette with loose strings.
i will be 68 this year and i have had to quit a job i loved and needed and now still have to work on my feet for 4-5 hours a day. in order to do this i spend much of my day in-between chores iceing and heating. the only exercise i can do is water X and i pay dearly for that with shaking hurting legs.
i can no longer particapate in actives that i did before the use of a statin and my big fear is that this will never heal.
i want to be part of a class action if there is one that fits my problems.
i got off the statins one week before the wedding and although it was better right away as time goes on i am worse and it looks hopeless.
HELP

Posted by
melvin burton
on
A year ago I had blocked arteries resulting in 4 stents being implanted. My 40 something heart surgeon put me on Lipitor which I resisted but he said that he was on it so don't worry. I took my prescription for a month. My Cardioligist changed me to Crestor because she said it was a better drug. I started having joint pains, I complained and she put me back on Lipitor. I cut my intake to a half dose for the next 6 months and exercised regularly. About a year later I started to get weak knees and had trouble climbing the stairs so I came off the :Lipitor. Next I pulled a knee tendon, then a heel tendon and now I have trouble walkingl. Before Lipitor I was an active 75 year old man, biking, daily walking and swimming. I hope I'll get the use of my legs back. My wife had a similar experience with Lipitor.

Posted by
sergio omar
on
While recuperating from a foot, and Achilles tendon injury. And have been successfully in physical therapy, and almost ready to go back to work without any surgery. I was place on Lipitor (Aotvastatin) 20 MG, for highTryglycerides. Then everything in my life went downhill from there, with intense muscle, joint and tendon pain, even causing a longitude split tear in the Peroneous Brevis tendon which was fine in previous MRI`s, along with foot structure weakness. Now I`m facing mayor surgery from which I might never fully recovery, nor be able to return successfully to my line of work as a Machinist CNC, a very rewarding trade.
Also I never suffer from Gout Attacks before, but now I do. Statin cause my Uric Acids to go off the charts causing gout Attacks for 3 painful weeks-the worst pain ever. I never ever drink alcoholic drinks, and eat very little red meat, or shellfish food which also might cause Gout attacks over a life time. BTW 6-9 cherry's a day, and 8 once of tart cherry juice reduce my gout attacks almost immediately.
Came to find out by taking the SMARTSTATIN TEST, that I`m 4.5 times unable to metabolize Statin, which put me at 23% of the population to have Statins Induced Myopathy. BINGO.
I will continue to monitor my muscle and joint pain, and will never ever stop telling people of the negligence of doctors whom prescript statins as the first response to treat high cholesterol.
I`m taking coQ10 for life which helps repair the damage statin drugs cause, and fortify the heart and muscles.
coQ10 is a powerful antioxidant that has been shown to be beneficial for heart health by protecting LDL cholesterol from oxidation and by re-energizing the mitochondria in the heart cells, which is where energy metabolism occurs. CoQ10 may also help lower blood pressure. And is produce naturally in the liver, but statins drugs brings coQ10 to dangerous low levels. Not enough coQ10 in the body, its common in cancer patients, and heart failure victim's. So take coQ10 please.
Also I`m now taking Omega3 krill oil pills; turmeric pills( Indian spice found in curry which are made into pills OTC that lowers LDL and plaque built-up in arteries as well as inflamations); vitamin D3 for bone and join strengthening and B3 for inflammation and to keep cholesterol at optimist levels lowering LDL and bringing HDL up; diet free of sugar and low carbohydrates, and I hope to exersice soon after my foot surgery.

Posted by
Martrese Young
on
I am a 68 year old female. I began taking statins 3 years ago for moderately elevated cholesterol. I also have diabetes for past 6 years. The first statin was simvastatin and after just a few days I developed hives. stopped the drug. A few months later I was put on Crestor and within five days I had severe muscle pain in both thigh muscles and had difficulty going up the stairs. Reported this to my MD and stopped the drug. Symptoms resolved quickly. Several months later, my MD suggested I try Pravastatin, he believed it had fewer side effects. The muscle pain returned after a few days on this drug, but I stayed on the drug for 27 days trying to be a good patient. The muscle pain became severe, with cramping in muscles I never knew I had . Like front of shin bone and top of feet. Stopped the drug but the symptoms did not resolve. I suffered for a full 2 years like this and my activity was compromised. I did finally see relief after getting very ill for 1 month after a Hep B vaccine. My muscle pain was greatly dinminished but it is still an issue. I believe that the statins caused this. I did not have a muscle biopsy or EMG because after research,patients who did reported severe pain with this and an exacerbation of their muscle pain. I was in enough discomfort and did not want anymore. I am a nurse dealing with many heart patients who take statins and I think the problem is more widespread than is reported.

Posted by
sergio omar
on
While recuperating from a foot, and Achilles tendon injury. And have been successfully in physical therapy, and almost ready to go back to work without any surgery. I was place on Lipitor (Aotvastatin) 20 MG, for highTryglycerides. Then everything in my life went downhill from there, with intense muscle, joint and tendon pain, even causing a longitude split tear in the Peroneous Brevis tendon which was fine in previous MRI`s, along with foot structure weakness. Now I`m facing mayor surgery from which I might never fully recovery, nor be able to return successfully to my line of work as a Machinist CNC, a very rewarding trade.
Also I never suffer from Gout Attacks before, but now I do. Statin cause my Uric Acids to go off the charts causing gout Attacks for 3 painful weeks-the worst pain ever. I never ever drink alcoholic drinks, and eat very little red meat, or shellfish food which also might cause Gout attacks over a life time. BTW 6-9 cherry's a day, and 8 once of tart cherry juice reduce my gout attacks almost immediately.
Came to find out by taking the SMARTSTATIN TEST, that I`m 4.5 times unable to metabolize Statin, which put me at 23% of the population to have Statins Induced Myopathy. BINGO.
I will continue to monitor my muscle and joint pain, and will never ever stop telling people of the negligent of doctors whom prescript statins as the first response to treat high cholesterol.
I`m taking coQ10 for life which helps repair the damage statin drugs cause, and fortify the heart and muscles.
coQ10 is a powerful antioxidant that has been shown to be beneficial for heart health by protecting LDL cholesterol from oxidation and by re-energizing the mitochondria in the heart cells, which is where energy metabolism occurs. CoQ10 may also help lower blood pressure. And is produce naturally in the liver, but statins drugs brings coQ10 to dangerous low levels. Not enough coQ10 in the body, its common in cancer patients, and heart failure victim's. So take coQ10 please.
Also I`m now taking Omega3 krill oil pills; turmeric pills( Indian spice found in curry which are made into pills OTC that lowers LDL and plaque built-up in arteries as well as inflamations); vitamin D3 for bone and join strengthening and B3 for inflammation and to keep cholesterol at optimist levels lowering LDL and bringing HDL up; diet free of sugar and low carbohydrates, and I hope to exersice soon after my foot surgery.

Posted by
Ingrid Innes Clark
on
The last statin I was on I developed muscle pain and weakness in my hips and thighs. I also have fatty liver. My doctor took me off of the stations. I haven't had a statins in about a year, I still deal with pain and weakness, and liver pain (actually it's the other organs, because the liver is enlarged.)

Posted by
jetgear
on
back in 2011 i was given 80 mg of this simvastatin and is having a lot of muscle weakness, headachs, eye problems, and joint pain etc

Doctors was given me antibiotic saying that i was having sinus infection, in which was and wasnt the case. come to find out the statin drug was causing my sinus to act up, but the antibiotic wasn't doing anything for me went to a different doctor and he took me off the statin.
Come to find out that i have the Rabdo, myopathy, neropathy
cataracts.
Now i havetype2 diabeteies and along with blood work problems feeling tired all the time

Posted by
Fernando hernandez
on
I have been on statins over 10 yrs mainly Zocor(simvastatin)
I was having a heart rate over 170 bpm and also bad muscle pain. I have seen heart doctors and can seem to find anything.
My muscle pain was very painful I seen orthopedics doctors and have not been very helpful. I was taken off my statin and it has help me.

Posted by
Suzanne
on
Mechanism by which statins stop the production of insulin, causing diabetes: http://www.ncbi.nlm.nih.gov/pubmed/18599549

Statins also cause arterial calcification. http://www.siliconvalleyfit.com/blog/bid/363136/Statins-Deplete-Vitamin-K2-May-Promote-Coronary-Calcification
Warfarin causes arterial calcification.
http://www.greenmedinfo.com/article/warfarin-use-increases-risk-valvular-calcification
Vitamin K prevents arterial calcification, but also causes blood to clot. http://lpi.oregonstate.edu/mic/vitamins/vitamin-K
Blood clotting and arterial calcification are two different things, but trying to prevent one may cause the other.
My late husband was put on statins, had congestive heart failure, and immediately afterward, was given spironolactone and losartan-contraindicated for heart failure patients, causing hyperkalemia and kidney failure. There is a shortage of Vitamin K associated with chronic kidney disease: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847737/

He became diabetic, which impaired his ability to process potassium, in conjunction with the contraindicated drug combination. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC372558/

While in the hospital, he asked that his case history be used for teaching purposes (he had been a teacher). Little did I know what a can of worms I opened up when I researched his medications.

He died a few years later on a dialysis machine age 59. His dad died at 91, and his mom died at 67.

So when somebody dies a lot younger than their parents, something went wrong somewhere. The statute of limitations for medical malpractice is only one year. I waited too long to sue. But perhaps someone else can be alerted before this happens to them.

Look up all drugs you are taking and see what they are doing to your body, before it's too late.

Posted by
Foxman
on
I am not able to walk due to pain in tendons in knees ,feet also cannot close hands to make a fist hard to even touch fingertips to pad of Palm.This happened after being prescribed 40mg of Atorvastatin. If there's a class action I would like to be a part of this.

Posted by
Vicki H.
on
I had a heart attack on june 20th of 2011.(quadruple by-pass) I was great didn't even go to therapy. the doctor was pleased with my recovery. I had take Zocor 80 mg since I was 18 years old and had taken it for 20 yrs, lost health insurance and I stopped taking it on my own- even though it went to generic. I didn't take the generic and it took 5 yrs and I had a heart attack and by-pass surgery. after my surgery I was even up to walking 1 & 1/2 miles per day. then I was checked for cholesterol levels and my doctor raised the Lipitor to 80 mg and my middle toe started having sharp pains, I called and we swapped meds to pravastatin, 40mg. within the next 6 months I could not put shoes on could not walk, had to crawl around in the house. when I finally made my self get up n had to walk it was unbearable and was not steady on my feet and was very weak. could not work, could not cook or do anything around my house. could only wear rubber boots and would cry so hard when my husband had to pull them off,
soaked my feet in Epsom salt daily. I would lay in bed and cry because the pain would not go away. then one day leaving church my ankle popped and my foot begun to roll inward toward the ground. now Im walking in the inside of my ankle bones and still am not able to get around, these meds have ruined my legs and feet. not to mention my mental health.

Posted by
William Ray
on
Statins but me in the hospital for 6 days. Pancreatites and all the other side effects. I was left with anemia and still take iron supplements. The iron gives me diarrhea. This experience resulted in me losing my job because of taking time off.

Posted by
Sheri Stern
on
After about 6 months on Pravastatin I started to feel weak in my legs. On October 16, 2015 I could no longer walk. In the hospital I could not lift either leg off of the bed. After a muscle biopsy I was diagnosed with necrotic Myopathy - my muscles were dying. A devastating reality.

I spent a month in the hospital and nursing home for physical rehab. I AM 57 YEARS OLD. I have been unable to work for 3 months without pay.

I am looking for a class action to join.

Posted by
Eric henderson
on
I'm having joint pain, aching popping wrist, leg pain all over, also hair loss.

Posted by
Michigan2014
on
I have taken Zocor/Simvastatin for 10-15 years. I was diagnosed with extreme Diabetes II this year (blood sugar 330) by a new-to-me primary care physician. My previous physician told me for several years that I was pre-diabetic when my blood-sugar was in the 200s. I didn't know anything about diabetes to know that was a problem. Since my lipids were high, the new doctor also prescribed Crestor instead of the simvastatin and Metformin for the diabetes. During the 2 weeks I took Crestor my blood sugar kept climbing even while taking the Metformin. I did research on the web and found articles about the link between statins and diabetes. I quit taking all statins and my blood sugar began to reduce. I still take the Metformin but it easily keeps my blood sugar within or close to normal range. I also have a high creatin number. I fear I have permanent liver damage due to taking statins for so many years.

Posted by
Indiana
on
I have been prescribed Pravastatin Sodium 20mg by Apotex Corp. I have taken this drug daily since 11-11-14 and discontinued it because of bone pains and a visit to bone specialists who never asked what drugs may have been causing tendonitis in my right arm (tennis arm). I have been off this drug for over two weeks and my right arm is still hurting, but less. I believe I have damage to my arm because of this drug, even though my GP said you just feel it but it does no harm. I disagree with this "dismissal" of my experiences with this drug. For a time, while on this drug, I actually thought I had bone cancer since many joints in my legs and arm were causing pain to my joints.

Posted by
Illinois
on
I took Lipitor beginning August 2006 and through 2007. I was diagnosed with Diabetes type 2 at the time I began taking it.

Posted by
Tennessee
on
I have severe joint pain and also was recently diagnosed with gout in my right foot. I am also a Diabetic. I have been taking cholesterol medication for over 2 years. My joint pain is now affecting my ability to walk, as I am now using a walker or cane most of the time. I am in constant pain and I am no longer able to do the activities I normally do, such as driving and walking for exercise. I have trouble sleeping due to the severe joint pain I deal with every day.

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