Proton Pump Inhibitors Linked to Gastric Cancer, Severe Kidney Disease and Bone Fractures
Proton pump inhibitors (PPIs) are a group of drugs mainly used to relieve symptoms of acid reflux, or gastroesophageal reflux disease. PPIs have been linked to an increased risk of bone fractures, heart attacks, cardiac birth defects (only in Prilosec), and more recently chronic kidney disease (CKD). The risk of proton pump inhibitor side effects has been found to increase with long-term use. The FDA has announced label changes that will reflect the increased risk of a proton pump inhibitor fracture, particularly PPI hip fracture. No action by the agency has yet been taken involving Proton Pump Inhibitor kidney damage or PPI renal damage.
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Proton Pump Inhibitor Information
Prescription PPI medications in the proton pump inhibitor class include: (Generic name in parentheses)
- Dexilant (dexlansoprazole)
- Prevacid (iansoprazole)
- Prilosec (omeprazole)
- Zegerid (omeprazole)
- Protonix (pantroprazole)
- Aciphex (rabeprazole)
- Vimovo (naproxen and esomeprazole magnesium)
- Prilosec OTC (omeprazole)
- Zegerid OTC (omeprazole)
- Prevacid 24HR (iansoprazole).
Proton Pump Inhibitor Kidney Damage
Because some PPI medications are sold over-the-counter, they are potentially more at risk of being overused than prescribed PPI medications.
Chronic kidney disease is increasing in the US, with more than 20 million Americans now suffering with it, according to the American Society of Nephrology.
PPI Kidney Disease Studies
The JAMA study indicates that patients should use PPIs only when medically necessary. Dr. Morgan E. Grams, a kidney specialist at Johns Hopkins and another author of the JAMA study told CBS News that patients who require a long course of PPIs should routinely monitor their kidney function.
2015: Two studies suggested a link between PPIs and CKD. Dr. Pradeep Arora, a nephrologist and associate professor at the SUNY Buffalo School of Medicine and Biomedical Science in Buffalo, NY., said "It is very reasonable to assume that PPIs themselves can cause chronic kidney disease." Researchers also found that people taking a PPI had nearly twice the risk of dying prematurely.
The second study was conducted by researchers at Royal Brisbane and Women's Hospital in Australia, and Johns Hopkins University in Baltimore. They followed more than 10,000 adults with normal kidney function from 1996 to 2011 and found PPI users were up to 50 percent more likely to develop chronic kidney disease than non-PPI users.
2009: A study conducted in Copenhagen and published in Gastroenterology reported that PPI use may produce a "rebound"acid effect, likening the condition to "dependency"on the medications. Researchers found that patients have almost impossible difficulties in stopping PPIs because the medications eventually cause the same problems they are supposed to treat. This phenomenon, called "rebound acid hypersecretion," can occur after taking prescription-strength PPI medication for just two months. Researchers concluded that this rebound effect can continue for up to three months after discontinuing the PPI.
PPI Kidney Disease Lawsuits
In 2017, a lawsuit files against AstraZeneca and Proctor & Gamble, alleging that use of Nexium and Prilosec caused a woman to develop chronic kidney disease. The lawsuit, filed by Wanda Stafford, claims the companies failed to warn consumers about the risk of side effects linked to the medications. The lawsuit seeks punitive and compensatory damages.
Proton Pump Inhibitor Bone Fractures
An editorial accompanying studies in the May issue of the Archives of Internal Medicine noted that proton pump inhibitors have US sales of $13.9 billion annually. The same editorial argues that proton pump inhibitors have been over-prescribed for inappropriate uses.
Proton Pump Inhibitor Warning
Over-the-counter proton pump inhibitors are recommended only for 14 days of continuous use.
Approximately 15 million people in the US alone are taking either over-the-counter or prescription PPI medications, according to CBS News. In 2013, the PPI Nexium was the second-best selling drug in the pharmaceutical industry, generating over $6.1 billion in sales worldwide for AstraZeneca, as reported by Medscape.
Proton Pump Inhibitor (PPI) Legal HelpIf you or a loved one has suffered kidney disease or bone fractures as a result of using any of the above mentioned products, please click the link below and your complaint will be sent to a Drug and Medical Device lawyer who may evaluate your claim at no cost or obligation.
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