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Nexium Use and Increased Risk for Fracture

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Washington, DC: Proton pump inhibitors (PPIs), including Nexium (esomeprazole), which are used to treat heartburn and gastroesophageal reflux disease (GERD), ulcers in the stomach and small intestine, and inflammation of the esophagus, can cause bone fractures.

According to data from a study published in the Annals of Family Medicine in 2011, researchers found that patients taking PPIs long-term were 30 percent more likely to suffer fractures than patients who did not. Meanwhile, patients who used high doses of the medications had a 53 percent higher risk of suffering a hip fracture. The study was involved an analysis of 11 studies of PPIs.

This follows information released by the Food and Drug Administration from its review of PPIs, which stated that high doses or prolonged use of PPIs, including Nexium, may boost the risk of bone fractures. The agency advised doctors to consider lower doses and shorter-term therapy. According to the agency, the risks are greatest in patients older than 50.

Nexium Fractures Lawsuits

Plaintiffs in the Nexium bone injury lawsuits, which were centralized (In re. Nexium (Esomerprazole) Products Liability Litigation, MDL Docket No. 2404), allege that AstraZenaca, the Nexium manufacturer, knew about the risks of broken bones but did not disclose the risks to the consumers so that they could continue selling more Nexium. The plaintiffs claim the drug caused osteoporosis, loss of bone density and/or Nexium bone fractures.

Nexium Studies and Research

On March 14, 2013, the FDA Pediatric Advisory Committee said that observational studies suggest that proton pump inhibitor therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist or spine in patients who received multiple daily doses and long-term PPI therapy. In April 2012, MHRA, which is responsible for regulating all medicines and medical devices in the UK, published an article revealing that there is recent epidemiological evidence of an increased risk of fracture with long-term use of PPIs (Proton Pump Inhibitors), including Nexium.

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Christina developed heartburn after her first child was born and says she took Nexium religiously for about five years. She remembers the date of her first Nexium fracture: it was July 4th and she could see fireworks from the hospital.
“I just tripped and fell but broke my ankle in three places,” Christina says.


Posted by

I have been taking nexium for 2 years and
Now I'm having bone pain and not sure why.
Only thing I can think of the cause is anti acid.

I see most brands say it depremiered calcium.

I'm 25 and never got this pain until I stated to run and workout.

Posted by

I have been taking high doses of Nexium for years--I'll have to go back to check my records to be precise. I am a 52 year old female in good shape and physically active. Recently, I broke my ankle severely just walking in my back yard. Had I known what I have recently discovered about Nexium I would never have taken it. My concern is that I may now have such brittle bones that I will no longer to be as physically active as I enjoy. Riding horses has been my life-long avocation and I can't imagine living without riding.

Posted by

I have been taking Medium for years. I never realized it could result in bone loss and fractures. I am about to go on permanent disability because the pain prevents me from doing my job as a special education preschool teacher. An xray confirmed the diagnosis and I am having a CAT scan of my neck and upper spine this week to explore the extent of the injury.


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