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Proton Pump Inhibitors Linked with Higher Rates of Gastric Cancer


Santa Cruz, CA: A new study on the use of proton pump inhibitors (PPI) in patients who have been treated successfully for Helicobacter pylori shows that the drugs more than double the risk for gastric cancer.



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Proton Pump Inhibitors Gastric Cancer Risk

The study does have several limitations, including the fact that it is observational and was done in Hong Kong, where there are well recognized specific risks for gastric cancer in Asian patients, including diet and high rates of H. pylori.

However, according to the authors of the study, published online in Gut, on October 31, the results show a "clear dose-response and time-response" trend in PPI use and gastric cancer. Therefore, they state, the risk observed suggests the need for "caution when prescribing long-term PPIs to these patients even after successful eradication of H. pylori."

Led by Wai Keung Leung, MBChB, MD, from Queen Mary Hospital, Hong Kong, the study looked at H. pylori infection and its relationship with gastric cancer, among other outcomes. They found a greater associated risk for gastric cancer with longer duration and more frequent use of PPIs.

Despite the study’s limitations, Dr Leung and colleagues state that, to their knowledge, "this is the first study to demonstrate that long-term PPIs use, even after H. pylori eradication therapy, is still associated with an increased risk of gastric cancer. This is likely related to the profound acid suppression of PPIs that worsens atrophic gastritis, particularly in those patients with established gastric atrophy as a result of chronic H. pylori-induced inflammation."


 

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PROTON PUMP INHIBITOR GASTRIC CANCER LEGAL ARTICLES AND INTERVIEWS

Proton Pump Inhibitors – More Harm than Good, especially in COVID-19 Patients
Proton Pump Inhibitors – More Harm than Good, especially in COVID-19 Patients
December 31, 2020
Santa Clara, CA Over the past several years, Proton Pump Inhibitors (PPI) have been linked to serious health complications. And more recent studies indicate that these acid reflux drugs do more harm than good. One such study opines that PPI exposure increases mortality in COVID-19 patients. Other studies suggest PPIs can damage major organs and regular use of PPI is linked to a higher risk of being diagnosed with type 2 diabetes and serious skin reactions such as life-threatening Stevens-Johnson Syndrome. And there is more…

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“Acid Reflux Drugs Caused my Type 2 Diabetes”
“Acid Reflux Drugs Caused my Type 2 Diabetes”
November 28, 2020
Phoenix, AZ Ten years ago Gary Phillips was diagnosed with type 2 diabetes. He had taken proton pump inhibitor (PPI) medications for acid reflux issues at least once a day for about 13 years but only knew that the medications were linked to diabetes when he read about PPI lawsuits. Unfortunately the meds worked— so he kept taking them. Now he takes insulin shots.
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Regular Acid-reflux Drug Use Linked to Higher Risk of type 2 Diabetes
Regular Acid-reflux Drug Use Linked to Higher Risk of type 2 Diabetes
October 25, 2020
Santa Clara, CA During this Pandemic there is also an epidemic that has been growing for decades and it is just as dangerous, perhaps even more so, than COVID 19. And drugs known as proton pump inhibitors or PPIs are feeding this epidemic: type 2 diabetes.
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READER COMMENTS

Posted by

on
I was given this type of medications for 8 years when all I really needed was to be told that this along with the use of Excedrin was only irritating the ulcers. I finally was admitted to the hospital at 88 pounds and had lost 4 pints of blood . I was barely alive. Now 2 years later I am finally ulcer free but I had them for 8 years. And the medications were making me a lot worse.

Posted by

on
Prolonged use of Prilosec and an elevation of kidney function test results. I am wondering if this is an ongoing issue with PPI's .

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