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Proton Pump Inhibitor Victim "Furious" with Manufacturers

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Rochester Hills, MII'm not mad at the doctors who prescribe these Proton Pump Inhibitors, but I sure am furious with the manufacturers," says Lilly, "and I am furious with the FDA for allowing these drugs to harm people."

Proton Pump inhibitors have been linked to hip fractures, and stomach and esophagus cancer. They have also been linked to stomach polyps, which Lilly is suffering from. The Mayo Clinic says that "long-term use of proton pump inhibitors (PPIs), which are medications used to treat gastroesophageal reflux disease (GERD), has been linked to fundic gland polyps."

Lilly's doctor had prescribed a number of meds but nothing worked for the pain of GERD until she went on Aciphex, a proton pump inhibitor (PPI). "I was taking Aciphex for about five years and I didn't have any problems," says Lilly. "I didn't feel the necessity to get a check-up and it never occurred to me that the drug might be causing a problem. I had some pain that went away in a day or so and I just assumed the drug was doing its job."

But Lilly's pain was getting worse so she went to a gastroenterologist. "She showed me a picture of my stomach and it was full of polyps, including a few big ones," Lilly explains."I was stunned. I was even more stunned when she told me that she had attended a seminar in 2009 that linked proton pump inhibitors to stomach polyps. And my regular doctor was stunned when I told him.

"The gastroenterologist suggested I see her husband, a gastroenterologist surgeon. He wanted to tighten the opening to my esophagus to prevent the reflux—the bile that forms in the stomach—that is causing the damage. He also said my stomach might have to be removed but he wouldn't know until they got in there. I walked out and never went back.

"I mentioned this incident to my ENT doctor and he advised me to see another gastroenterologist sooner than later—he didn't like the wife-husband connection. So I saw another specialist last month and the polyps are worse. He confirmed that the PPIs are the cause. I am still taking Omeprazole—which is another PPI—even though I know it is causing damage.

(Stomach polyps, which are small growths on the lining of the stomach, occur infrequently, and show up in less than 1 percent of patients who undergo an upper gastrointestinal endoscopy. Although stomach polyps are usually benign, some types can be a precursor to stomach cancer.)

"I'm damned if I take these PPIs and damned if I don't," says Lilly; she is afraid that the polyps could turn into stomach cancer but she hasn't found anything else to take the pain away. Meanwhile, her gastroenterologist is trying to wean her off them. "So far I am doing OK and the pain hasn't worsened," Lilly adds. "The doctor wants to wean me off it completely but I am worried because I have to take something for this acid reflux. There are so many other meds I have taken but nothing works.

"When I go to bed it seems to get worse; the pain radiates out from my breastbone through my chest wall and sometimes into my arms. It feels like a heart attack and I have had so many EKGs it's not funny—they told me that I have a beautiful heart; too bad my stomach wasn't as beautiful.

"Last month my doctor snipped off a few of the largest polyps for a biopsy and I am waiting for the results. I am booked for a colonoscopy December 14—now he wants to make sure there are no polyps in my colon.

"I think there are too many meds like PPIs that cause awful side effects. But I don't know what else I could have done and that is the dilemma. I know so many people over the years who suffer from acid reflux and now I warn them not to take these drugs. I think they get these PPIs on the market too fast, without realizing what damage they cause.

"All I can do is wait and see—I can't set my goals any higher. My son was pretty upset when I told him about PPI side effects and he told me to get hold of a lawyer."

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READER COMMENTS

Posted by

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I too have been on aciphex and Prilosec, they can stop ulcers but stomach cancer. Harvard said it is better to take the old fashioned mylanta and pepto bismol, as Pepto bishop is a natural inhibitor to h.pylori.for a blood pressure medicine I was put on sometime ago. for synthroid which I didn't need. Armor thyroid wouldn't do this. western medicine. and he is going to hear about this. I have been throwing up for almost a year and finally went to the gastro/. we can treat and test they just don't heal, have you tried stem cells?

Posted by

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I have stomach polyps and have been trying to find something to get off ppi's with no luck have tried to stop taking them but have not been able to.been takeing them for years.was not told ppi's could cause polyps ,wish I had a answer.

Posted by

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A doctor kept me on nexium for about 10 yeats.i use to ask him why do plopys keep growing in me like a garden he said he didnt know.so he just kept going in removing them out of my stomach.one time he removed them so much i thought i was going to dye.but on the last surgery he said iam taking you off nexium i think thats ehats causing the ployps.few months later when back for surgery i will never forget i her the dr. Tell the nurse let her be last.she always have alot of ployps.he took the other lady first but the joke was on him that lady had all the ployps and he spent all his time on her.i had off nexium.imade sure i got all my records.but one day he willhave to pay

Posted by

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It's a long story but my elderly mother passed away recently, (Monday) due in part, to an gastric intestinal hemorrhage. The doctors could not stop the issue due to sepsis setting in. Soon after her diagnosis, we had to let her go. (took her off the medications she was on in the hospital.) She died a short time later. I know she has taken Prilosec for years and took it a few weeks ago, because of acid reflux she thought was due to a hiatal hernia.
I don't know if I should file a suit against the makers of Prilosec or not.

Posted by

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The lawyers seem to be making big profit from this. Is there a way for someone to apply for the $ set aside without a lawyer.

Posted by

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I have been on omeprazole and other PPIs since the 1990's due to GERD,,,,I am now set to have 30 stomach polyps removed June10,2016,,,,one has shown to be dysplasia from a biopsy 2 weeks ago,,,,my doctor has chosen to wean me off the PPIs for good, not sure how that will work out yet,,,,also not sure what the biopsies on these 30 polyps will show,,,,I am concerned for sure

Posted by

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In February 2016 I had both the endo & colonoscopy scopes they discovered I believe 1 or so polyp in my stomach however they removed 14 or so polyps from my colon and there were more to be removed. April 2016 I returned for another colonoscopy and they removed a additional 15-20 polyps and more remain. They did a genetic testing to determine if they are removing just my large intestines or both Small & large intestines.
I have been on nexium since 2005 when they repaired a hernia & my esophagus they told me I had to be on it for life. A few years prior I was on others acid reduction medication. How can the FDA not mention this or allow such medication?

Posted by

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I have taken PPI'S for 20 years-first Prilosec, then switching to Nexium. It is frustrating that when something works, it then is found to do more harm than good. The acid reflux is an unbearable discomfort, causing one not to want to eat. I have asthma which triggers coughing/wheezing which adds to the cycle of the burning heartburn. Many times, I just feel like I could 'blow fire' like a dragon! Today, I am now trying to get off of the PPI'S.

Posted by

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I've been on Nexium for over 15 years and was not aware it could cause stomach polyps. My polyps were discovered during an endoscopy 4 years ago and for the rest of my life, I will need to have an annual endoscopy to remove and monitor my stomach full of polyps. I pray none will turn cancerous. I'm now trying to get off Nexium but that is a difficult process. I am so very sorry I ever took the first Nexium pill and think the drug companies should be required to communicate this side effect. My GI dr. said he is seeing more and more cases of stomach polyps.

Posted by

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She has been on Prontrix for 4 years to aid in acid due to taking Norco for tennis elbow. Dr. Never checked for cancer during this time. Now no stomach these medicines state 7 to 10 days, if taken for 8 weeks Dr. should be testing due to it causes cancer. 4 f-in years. Many people like my wife feel you should never question the doctors. We need to change this type of do as you want attitude.

Posted by

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i have learned the hard way to research every medication the doctors want to put you on. you have to decide for yourself if it is worth the risk of the side effects. i have been on numerous meds for my acid reflux and none of them work. my last endoscopy showed more polyops and now i have another one in my uterus. i am searching for an alternative option

Posted by

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I've been taking Nexium for years. Two weeks ago I had an upper endoscopy and they found and removed a number of polyps. Thank God that they came back benign. I have stopped taking the Nexium. I thought that was one that was supposed to heal things but I am not going to take them anymore. My heartburn is definitely worse, especially when I lay down. The burn comes up the back of my throat and feels awful. I remember feeling this when I was still pretty young and didn't know what it was. I just knew that sometimes something happened to make my throat burn. I had no idea it was reflux. I know there are some natural remedies for this and I'm going to try them. I would consider the surgery too since it should eliminate the need for acid blockers. Plus the surgery would end up paying for itself in the long run since those medications are so expensive.

Posted by

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try to take time out to relax, sit straight and slowly chew a peeled sliced Apple. If you don't have an apple try cutting up lettuce finely and slowly eating it, enough to fill your stomach. Try other high fibre vegetables such as cucumber, carrot or cabbage raw or cooked. Try to avoid other medications. Also don't bend over after eating. Try to keep calm and stay straight at all times

Posted by

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I would love to get off PPI's the doctors won't offer me surgery because my ppi's are working well for me.
What can I do I tried to get off of them and can't. Motility and ph tests came back abnormal, what can I do?

Posted by

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I would love to get off PPI's the doctors won't offer me surgery because my ppi's are working well for me.
What can I do I tried to get off of them and can't and motility and ph tests came back abnormal, what can I do?

Posted by

on
Fifteen years ago, I had a standard (non-floppy) Laparoscopic Nissen Fundoplication performed by a highly skilled surgeon. It was the best decision I ever made. I have never again experienced acid reflux or heart-burn.

Although PPI's had given me complete relief from my GERD, I was afraid that taking PPIs for more than 3 months continuously would be very detrimental to my health. Now, as I read comments from others who have taken PPIs long term, I realize I was correct in having concerns about their long term use.

I believe that for some people who may be good candidates, the Nissen Fundoplication can be a blessing (when performed by a skilled surgeon).

But, life is full of risks and with Nissen surgery there are never any guarantees. Some people have gambled and lost; while others, like me, have been fortunate enough to have found a cure through surgery.

Medications (PPI's and acid blockers) treat the symptoms of acid reflux. Surgery to strengthen the lower esophageal sphincter muscle (LES) treats the actual cause of the un-blocked reflux.

Given that taking PPI's long term is a big risk, in many cases, it may be that having Laparoscopic Nissen Fundoplication surgery is the "lesser" of the two risks. However, it should be noted that Nissen surgery forever "alters" the human anatomy - and in that sense, it is not reversible.

A new surgical option just became available. Through minimally invasive keyhole surgery, a link of magnetic titanium beads is placed around the lower esophageal juncture to strengthen the LES sphincter muscle. The system of magnetic beads is called "LINX." According to the manufacturer, this band of magnetic titanium beads controls GERD permanently. And, the surgery is completely "reversible." This may be an option worth investigating. If I had it to do over again, I would try the LINX option first - before Nissen fundo surgery. Popping meds forever is the last option I would want.

Posted by

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I'm not a doctor, but i would be hesitant to believe that a b-vitamin complex is going to cure GERD. On the other hand, i guess its worth a shot if you don't take so much its harmful. The other thing i've read about PPI's and other heartburn medications in general, is that they also make people more susceptible to food borne illnesses. The primary reason for this is that stomach acid is not bad in and of itself. Quite the opposite, it serves very important purposes, digesting food, and killing harmful bacteria/viruses that you ingest. When you have less stomach acid, or stomach acid that is less acidic due to heartburn medications, harmful pathogens can pass through more easily, at least thats the theory anyway. I get heartburn, and sometimes its so bad i break out the tums, but when my doctor suggested a PPI i said no friggin way.

Posted by

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PPI's also cause Barrett's Esophagitis, which can lead to cancer of the esophogis. I have Barrett's right now and the physician that prescribed it, did an endoscopy on me and left a message on my answering machine, informing me of the Barrett's, which I now have. I was on Nexium for years. My internest is now telling me to lower my dose of protonix. I sleep sitting up every night. Diet has not helped. I am considering surgery, but am quite concerned about that also. I am at the point of not trusting any new medications, the pharmo company's and physicians. What do you do?

Posted by

on
and all your dr had to tell you was to take a b-complex vitamin everyday and this would have stopped this acid from forming. dont be so leanient on your dr they all know this and hold it from the pulic.

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