Plavix Side Effects
Patients who take Plavix to ward off heart attack or stroke may find that the risk of Plavix side effects is greater than the potential benefit. Studies suggest a link between Plavix and bleeding and a risk of Plavix interactions with other medications. Patients who have been harmed by use of Plavix may be eligible to file a Plavix lawsuit against the drug's maker.
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Normally, platelets in the blood clump together and form blood clots that stop bleeding. However, in some patients, these platelets clump together in narrow arteries, resulting in a clot in the artery, which can prevent proper blood flow. When blood flow is stopped in arteries that lead to the brain, the brain does not receive an adequate supply of oxygen, which can cause a transient ischemic attack. When arteries to the heart are blocked for a short time, patients experience angina (chest pain). When that blockage occurs for longer, patients experience a heart attack.
Plavix is prescribed to help prevent blood clots from forming in the arteries. The top-selling drug is made in the US by Bristol-Myers Squibb and internationally by Sanofi-Aventis.
"Patients at risk for heart attacks or strokes who use Plavix to prevent platelet aggregation will not get the full effect of this medicine if they are also taking Prilosec," said Mary Ross Southworth, Pharm.D., of the Division of Cardiovascular and Renal Products in the FDA' Center for Drug Evaluation and Research.
Because Plavix does not work properly until it is converted or metabolized into its active form by the liver enzyme CYP2C19, Prilosec's blocking of that enzyme reduces the effectiveness of Plavix. According to the FDA, information provided by the manufacturers supported "the existence of a significant interaction that could negatively impact a person's health."
Other drugs that patients are urged to stay away from while taking Plavix include Nexium, Tagamet and Tagamet HB, Diflucan, Nizoral and Prozac.
Plavix CHARISMA Study
Researchers further found that in a subgroup of participants who were given the combined medications as a preventative measure, but were not symptomatic of stroke or heart attack, the risk of moderate to severe bleeding increased. Furthermore, the risk of death increased in patients who were given clopidogrel. Among asymptomatic patients, the rate of death from cardiovascular causes was 3.9 percent among those who were given clopidogrel and 2.2 percent among those given a placebo.
Plavix Stomach Bleeding
Researchers recommended that some patients who took Plavix be switched to aspirin and a heartburn medication because the aspirin not only appears safer, but is also reportedly less expensive than Plavix.
Lawyers are currently investigating the possibility of a Plavix lawsuit against the makers of the anti-clotting drug.
Register your Plavix ComplaintIf you or a loved one has suffered abdominal bleeding while taking Plavix, you may qualify for damages or remedies that may be awarded in a Plavix class action or lawsuit. Please click the link below to submit your complaint to a lawyer for a free evaluation.
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Plavix Gets Black Box Warning
The FDA has warned that Plavix may not work for some people, putting them at greater risk for heart attack and stroke. The blood-thinner (anti-clotting) drug will get a black box warning and doctors have been told to consider alternative medications--such as aspirin-- for patients who cannot process the drug.