The study, which examined more than 225,000 pregnancies covered by Tennessee Medicaid from 1995 through 2007, included 23,280 pregnant women who had prescriptions for antidepressants before becoming pregnant. Of those, 75 percent did not fill their prescriptions in the second or third trimester while just under 11 percent used antidepressants throughout the pregnancy.
Researchers found that women who filled antidepressant prescriptions during their second trimester were more likely to give birth prematurely, by up to five days. They further found that use of selective serotonin reuptake inhibitors (SSRIs) during the third trimester was associated with infant convulsions. The study did not examine what further effects the use of SSRI antidepressants—a class of drug that includes Celexa—had on infants.
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The increased risk to the heart was reportedly not seen in other, similar antidepressants.
In December 2011, the US Food and Drug Administration (FDA) updated its warnings about the use of SSRI medications while pregnant. At the time the FDA noted that although one study suggested a link between use of SSRIs while pregnant and an increased risk of persistent pulmonary hypertension of the newborn (PPHN), recent studies have produced conflicting results. FDA stated that any conclusion about the link between SSRI use while pregnant and PPHN was premature.