Toronto, ONWith aging Baby Boomers continuing to be put on statins to fight the so-called “bad” LDL cholesterol (suspected of causing arterial plaque that leads to heart disease), a growing concern surrounds the potential for diabetes associated with higher-dose statins. The potential for Lipitor diabetes is among those concerns.
To that end, a new study by Canadian researchers suggests the diabetes risk amongst higher-potency statins such as Lipitor remains higher than lower-potency statins. Lipitor has been described as the most popular statin, used by patients to control their Lipitor mdl levels.
According to the Edmonton Journal (5/25/13), Dr. Muhammad Mamdani and colleagues were dissatisfied with previous studies that afforded conflicting results. Thus, Mamdani et al scrutinized the records of more than 470,000 individuals age 66 and above who resided in the province of Ontario and without symptoms of diabetes prior to starting on a statin.
Lipitor was one of three statins found to increase the risk of developing type 2 diabetes. Mamdani and colleagues estimated that for every 1,000 patients taking a higher-potency statin such as Lipitor, six to 10 patients will emerge as symptomatic of type 2 diabetes. Mamdani identified the risk as relatively small. “But there are a lot of people taking these high-potency statins. In fact, atorvastatin is by far - by far - the most popular statin.”
Margaret Clark knows all about that risk and the potential to see that risk realized. The South Carolina plaintiff filed a Lipitor diabetes lawsuit March 25 in US District Court for South Carolina, Charleston Division, Case No. 2:13-cv-00796, alleging that Lipitor manufacturer Pfizer failed to adequately warn physicians and consumers about the potential for diabetes associated with Lipitor. Clark was diagnosed with atorvastatin type 2 diabetes.
Clark, it was reported, was put on Lipitor in 1999 to combat high levels of LDL cholesterol and took it for 10 years before developing atorvastatin type 2 diabetes in 2009, in spite of a healthy lifestyle and a body mass index (BMI) of 24.8. Health Canada, the Canadian counterpart to the US Food and Drug Administration (FDA), mandated a label change to Lipitor and other high-potency statin drugs to reflect a small, increased risk for diabetes.
Mamdani, director of the applied health research center at the Li Ka Shing Knowledge Institute at St. Michael's Hospital in Toronto, maintains that doctors and their patients have to individually weigh the risks between the possible onset of diabetes, against potential heart risk tied to Lipitor mdl cholesterol levels that remain unchecked.
The Women’s Health Initiative (WHI) statin study, published in January of last year, concluded that statin medications such as Lipitor mdl used by postmenopausal women were associated with an increased risk for diabetes mellitus (DM). “This may be a medication class effect. Further study by statin type and dose may reveal varying risk levels for new-onset DM in this population,” the researchers wrote.
Mamdani’s more recent study appeared in the prestigious BMJ, the Journal of the British Medical Association.
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