However, the authors stated that regular reliance on acid-suppressing drugs such as Nexium and Prilosec, among others, could increase the risk for PPI fracture.
The Archives of Internal Medicine made that very point back in May. "For most patients the adverse effects of PPIs outweigh the benefits," wrote Mitchell H. Katz, MD.
The concern stems from with the sheer number of consumers who use proton pump inhibitors to treat dyspepsia and other maladies: No fewer than 113.4 million prescriptions are filled for PPIs each year, according to the Archives. With sales of $13.9 billion annually, PPIs can boast status as the third-highest selling class of drugs in the US.
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"Besides increasing the risk of fractures and C difficile infection, PPIs are also known to increase the risk of both hospital and community-acquired pneumonia," Dr. Katz continued. "The increases in the risk of Clostridium difficile infection with PPIs are not at all modest, reflecting the likely importance of gastric acid in protecting against infection from this pathogen...meta-analysis in [the 05.10.10 issue] of the Archives shows that higher-dose PPIs…were not more effective in decreasing the rates of rebleeding, surgical intervention, or mortality than lower doses."
The conclusion is that the benefits of proton pump inhibitors may not justify the risks for many users.