The study linking the combined use of PPIs and Plavix to myocardial infarction involved a meta-analysis of 25 studies. Researchers examined the records of approximately 160,000 patients and concluded that patients who took a PPI along with Plavix faced a 31 percent increase in the risk of myocardial infarction, compared with patients who did not take the two drugs together.
The risk of death was seen to increase by four percent when patients took the two drugs together, which is not considered a significant increase.
According to MedPage Today on 8/26/10, the study was presented before the European Society of Cardiology.
Because Plavix can reduce the risk of heart attacks, the study suggests the use of PPIs with Plavix decreases Plavix's effectiveness.
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That risk increased in patients who took Nexium, Prilosec or other PPI medications at high doses for longer than a year.
Meanwhile, senior citizens who use proton pump inhibitors have been warned about the increased risk of fracture. Seniors are already at an increased risk of fracture and some doctors suggest their older patients have taken PPI medications for far longer than the recommended period.