Actos (pioglitazone hydrochloride) is a member of a class of drugs known as thiazolidinediones, which have been linked to bladder cancer, liver disease and cardiovascular issues. Actos side effects include increased risk of congestive heart failure (CHF), increased risk of rare but serious liver problems, an increased risk of fractures, and an increased risk for bladder cancer. A black box warning exists for Actos and heart failure, however, an Actos whistleblower lawsuit suggests a previously known but downplayed link between Actos and myocardial infarction (Actos heart attack). Actos is used to treat type 2 diabetes.
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Under the terms of the agreement, Takeda will establish a fund of between $2.37 billion and $2.4 billion, depending on how many Actos litigants opt into the settlement.
Over 4,000 cases are included in this agreement, and were coordinated in the U.S. District Court for the Western District of Louisiana, as well as lawsuits filed by about 4,000 people in Cook County, Ill., according to lawyers for the plaintiffs.
While Takeda denies any wrongdoing in this agreement, the settlement will recover some compensation for the victims who have been injured and, in some cases, maimed by bladder cancer while taking Actos.