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Lisinopril Side Effects May Include Hyponatremia

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Boston, MAIn a recent Medscape Today column, Northeastern University Assistant Dean Jenny A. Van Amburgh explained that lisinopril side effects can potentially include hyponatremia, a metabolic condition in which there is not enough salt in certain body fluids.

According to Van Amburgh, the medication's package insert shows hyponatremia as a potential adverse event associated with the drug, but there is no known incidence rate. Studies have reportedly indicated that patients taking 10–40 mg of lisinopril for varying periods of time (between six months and four years) showed some signs of hyponatremia and lower serum sodium levels.

In two of the cases, patients were reportedly given lisinopril a second time, and their serum sodium levels dropped once again. This led the researchers to conclude that the hyponatremia condition was likely a direct result of the medication, and not other factors, according to Van Amburgh.

Additionally, Van Amburgh went on to say that there were 17 cases of hyponatremia related to the use of ACE inhibitors published as of 2002, with five involving the drug captopril and nine involving enalapril.

Still, the author of the column writes that while it appears as though ACE therapy—including lisinopril—could lead to the development of hyponatremia even at the lowest doses, physicians need to consider other possible medical conditions that could be leading factors. Examples of these increased risk factors include patients with congestive heart failure and those on concomitant diuretic therapy, according to Van Amburgh.

Either way, it is important for doctors and physicians to recognize the potential risks, and make informed decisions when prescribing drugs such as lisinopril, Van Amburgh writes.

"Hyponatremia is recognized as a potential adverse effect of ACE inhibitor therapy, with grave consequences if left uncorrected. Both patients and providers should be aware of and monitor for the signs and symptoms of hyponatremia," she said.

According to the National Center for Biotechnology Information, lisinopril is typically prescribed to treat high blood pressure, and can also be used in combination with other medications to treat heart failure.

Other side effects of the medication can potentially include dizziness, excessive tiredness, decrease in sexual ability, difficulty breathing or swelling of the face, according to the NCBI. Overdose symptoms can often include fainting and lightheartedness as well.

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READER COMMENTS

Posted by

on
I came across this site while trying to search causes of low sodium. My sodium has been low for several years and I've also been taking lisinopril for quite a few years. There's been no found cause for the low sodium and I'm surprised to see lisinopril linked to it. My doctor has me on limited liquids and sodium chloride tablets 3 x a day but my sodium is still low. I have never fainted in my life and experienced two episodes of passing out in the past few years as well.

Posted by

on
xxxxxxx@yahoo.com
I am 60 yrs old. I have been taking Lisinopril for years and about 1 1/2 years ago I passed out, I had dizziness and confusion issues. I’m a pretty sharp person but After a fasting bloodwork, maybe 2 yrs ago I was referred to a kidney specialist. Suddenly I have low sodium. I am actually limited to the amount of water I consume. I’ve recently read about lisinopril and some frightening effects of this med. I believe I may have Hyponatremia. I want to know what I have to do to get someone to help those of us who’s medications cause medical conditions that are
Life-threatening. This is just sooo frightening

Posted by

on
It is sad to say, but I am finding comfort in reading all of the post concerning Lisinopril. I have been on this medication for a little over 3 years. I have experienced so many symptoms, but I kept thinking that it had something to do with my Graves Disease, which has been under control for at least the past 3 years. Every so often out of the blue, my left foot would swell. I have consistently had the hives, insomnia, dizziness, lightheadedness, blurred vision, confusion, delayed reaction, chest pains, bad stomach cramps, respiratory issues, and failed stress tests. I have spent a fortune going from doctor to doctor in pursuit of finding a cause for the illnesses I have been having. To no avail, every doctor has come up empty, but none has ever looked into the possibility that it could be the lisinopril. My left foot has been swollen for the past 6 months consistently and I could not get it into a shoe. Therefore, I was wearing an orthopedic boot until a solution was found. To no avail...the orthopedic doctor, the pcp, the rheumatologist, the endocrinologist, the podiatrist, and the cardiologist all came up empty. I have had every test you can think of ran to attempt to determine the cause, but to no avail, I do not have a medical diagnosis to explain the reasons why I experience all these symptoms along with the reason why my foot has stayed consistently swollen for 6 months.

Posted by

on
I was taking Lisinopril and i had such a dry cough i was miserable i told the Dr and she took me off of it

Posted by

on
I have been taking this medication(Lisinopril) for several years it first started fainting, I didn't know the there was a recall on this medicine ever I have have a have cough every night not sleeping very have good,coughing so much to pee pee comes out I have had,
hives, hoarseness, Blurr vision, stomach pain, tiredness, muscle cramp, itching then I had a reaction my top lip swollen when I woke up morning 3-2919. I have been telling my doctor all my symptoms for years. If there's any class-action I would like to join please call me334 540 xxxx

Posted by

on
~ 10 years ago I was told that I had colon cancer.
After 3 colonoscopies, 3 endoscopy, gallbladder radioactive test and a ultrasound, CT pelvic scans yet nothing found.
I have lived with it suffering fro 2:00am till about 6 am. Last week I was suffering and decided to review my med records. I discovered that back when this all started, I started lisinipril 2 weeks earlier. I have stopped taking the meds and I haven’t had any symptoms for 4 days. The last ten years have been hell. I am self employed and no matter how bad it’s been I get up take care of my family. No insurance has made getting med help hard to find. After going through my savings, I won’t be able to ever retire. I spent my life saving trying to fix me and survive, but it was the medicine that has caused all the pain. Sometimethe so called cure kills you.

Posted by

on
I was taking lisinopril for a lot of years. I lost 20 pounds so my Dr took me off of them about 8 months ago. I have spells with my stomach cramping, can't have bm. I recently started being dizzy to where it makes me nausea. This has been going on for 2 weeks and isn't getting any better. I'm almost 65 years old.

Posted by

on
I have suffered many nights and days suffering while on trips,embrassments, lips, Head, throat, head as big as a basketball, my family was scared nearly to death, we did not know what was happening, I went to hospitals n Ga, Ky, and NY while my dad was on his death bed! We were nsto Tha same hospital from this high blood pressure med. Lisinopril. I had to go to sleep treatments,sleep mask 3ct.

Posted by

on
Hi i been on this medication for a couple of years the first time and now I been on it for 7 years now and the first time I lost my hair in the middle thought it was due to just stress but it continued til I was off the meds. Now I been back on it for 7 or more years and I've lost alot more hair over the years . Also I feel like my tongue is swelling and I cant swallow anyone have these problems?

Posted by

on
After taking this bp drug Lisinopril I have high heart rate,fatigue and diarrea with stomach cramps.

Posted by

on
I have been taking Lisinopril for several years. Since then, I have been having a hard time retaining my minerals. I have ended up in the hospital several times with no potassium or magnesium. My heart rate goes crazy and my whole body shakes and cramps. I feel dehydrated and crave salt. The doctors say it's not from Lisinopril.(I take no other drugs) My liver enzymes are elevated and they don't know why.

Posted by

on
Pcp prescribed me 5 mg lisionpril nov 1st 2013 to protect my kidneys because I have diabetes,this medicine gave me heart palpations dizziness upon standinding chest tightened,November 25th admitted to ER had MRI,sonograms blood work, all come back negative. Now here in jan 2014 I can't hardly walk or stand without falling over,I'm to lightheaded to go to work,went back to ER still test negative,goin to a cardiologist for stress test. Anyone goin through this or can help please email me at leemason39@yahoo.com

Posted by

on
I've been on lisinopril for 7 years and have experience dizziness & lighthead. Not one time have i been told this this drug could cause significant liver damage.

Posted by

on
I've been on lisinopril for 7 years and have experience dizziness & lighthead. Not one time have i been told this this drug could cause significant liver damage.

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