According to the organization, whose DO NOT USE list appears on the website Worst Pills, Best Pills (www.worstpills.org), Actos is on the list of DO NOT USE drugs because of a long list of serious side effects, "of which bladder cancer is but the latest."
This is not the first time Public Citizen has taken issue with Actos, although in the past Actos was often mentioned alongside rival drug Avandia. In 2007, Public Citizen sent a letter to the US Food and Drug Administration (FDA) noting that it had obtained an internal FDA memo from 2002, which concerned heart failure in patients taking Avandia and Actos. According to that internal memo, the FDA had reports of 47 cases of heart failure requiring hospitalization. Of those, 25 were linked to Avandia and 22 to Actos.
READ MORE ACTOS SIDE EFFECTS LEGAL NEWS
The FDA has issued a warning that use of Actos for more than a year may be linked to an increased risk of bladder cancer. The warning came after the FDA received information from a study that showed an increased risk of bladder cancer in patients who took Actos for the longest and had the highest cumulative dose. The agency did not issue an Actos recall, although in France, sales of Actos were suspended after information about the link between Actos and bladder cancer was made available.
Lawsuits have reportedly been filed against Takeda Pharmaceuticals, maker of Actos. Initial arguments over consolidating the proceedings could be heard as early as December 2011.