Diabetes Medication Lawsuits
A number of diabetes drugs have been linked in studies and lawsuits to serious drug side effects, including acute pancreatitis and pancreatic cancer. Some class action diabetes lawsuits have resulted in settlements with the plaintiffs. Other lawsuits are just getting underway.
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Diabetes, a lifelong condition, causes a person's blood sugar level to become too high. Four main risk factors for developing type 2 diabetes are genetics, age, weight and ethnicity. Almost 26 million Americans have diabetes, and up to 95 percent of these cases are type 2 diabetes.
There are several classes of diabetes drugs that work in different ways to lower blood sugar (glucose). Sulfonylureas have been used to treat diabetes since the 1950s while the first drug in a new class of medications called DPP-4 inhibitors was approved by the FDA in 2006. Sitagliptin was the first DPP-4 Inhibitors approved, followed by a combined product of sitagliptin and glucophage and saxagliptin in 2007.
A group of dugs known as incretin mimetics includes Byetta, Bydureon, Victoza, Januvia and other medications.
Diabetes Drug Classes
- DPP-4 inhibitors (gliptins, or dipeptidyl peptidase-4)
- SGLT2 Inhibitors (sodium-glucose cotransporter-2 )
- Alpha-glucosidase inhibitors
- Bile Acid Sequestrant
Types of Diabetes Drugs
Avandia (rosiglitazone maleate) Associated risks: heart attack, bone fractures, liver failure, death.
Byetta (exenatide) Associated risks: acute pancreatitis, thyroid and/or pancreatic cancer. Byetta attorneys are investigating lawsuits for users diagnosed with Impaired Kidney Function; Kidney Failure; Hemorrhagic Pancreatitis; Necrotizing Pancreatitis and certain other cancers.
Invokana (canagliflozin) Associated risks: cardiovascular injuries, kidney failure and ketoacidosis, a serious condition where the body produces high levels of blood acids called ketones that may require hospitalization. Launched in 2013, Invokana has become a blockbuster for Johnson & Johnson. A recent FDA Public Health Advisory found that the SGL2-inhibitor is associated with diabetic ketoacidosis in otherwise healthy patients. Adverse event reports and clinical trial data also show that Invokana is linked with cardiovascular injuries and kidney failure. Invokana works by causing blood sugar to leave the body through urine and is the most popular medication in a class of Type 2 diabetes drugs called SGLT2 inhibitors, according to drugwatch.com. The FDA urges patients with any early warning symptoms, including nausea, vomiting, difficulty breathing, confusion, abdominal pain and unusual fatigue or sleepiness, to seek medical attention immediately.
Januvia (sitagliptin) (Januvia (sitagliptin) and Janumet (sitagliptin/metformin) are the first in a new class of oral diabetes medications, called dipeptidyl peptidase-4 (DPP-4) inhibitors.) Associated risks: acute pancreatitis, hemorrhagic or necrotizing pancreatitis, pancreatic cancer. A recent heart safety study June 2015 ruled out any association with Januvia and cardiovascular problems. The study also looked at other Januvia side effects and found that Januvia pancreatitis has some risk.
Victoza (liraglutide) Associated risks: thyroid cancer, pancreatitis, serious allergic reactions and kidney failure.
Farxiga (Dapagliflozin) Associated risks: ketoacidosis, a serious condition where the body produces high levels of blood acids called ketones that may require hospitalization.
Jardiance (Empagliflozin) Associated risks: ketoacidosis.
Onglyza and Kombiglyze XR (saxagliptin) Associated risks: ketoacidosis. The FDA in April 2015 found that patients in a clinical trial who took Onglyza have a 27 percent increased risk of hospitalization for heart failure. The agency also reported that Onglyza increases the risk of death from all causes, not just heart problems.
Rezulin (troglitazone) Associated Risks: liver and cardiovascular issues. Rezulin labels warn of increased risk of rare but serious liver problems.
Other diabetes medications are Alogliptin (Nesina, Kazano, Oseni) and Linagliptin (Tradjenta, Jentadueto).
Diabetes Drugs: Lawsuits Filed
The Cherokee Nation in May 2015 filed a lawsuit against Takeda Pharmaceuticals, accuses the company of "misbranding"Actos sold to the Cherokee Nation for uses as being not approved as safe and effective. Actos (generic pioglitazone) was sold in the treatment of Type 2 diabetes to help lower blood sugar levels.
Other lawsuits have been filed against the company indicating Actos could potentially cause bladder cancer. Patients are also warned the drug could cause congestive heart failure.
Farxiga, Jardiance and Invokana lawsuits are being filed nationwide on behalf of patients who say they weren't warned about adverse side effects like ketoacidosis, heart attack, stroke, and kidney failure. The FDA issued a safety communication on May 15, 2015 for diabetes patients using Farxiga, Jardiance and Invokana . The entire SGLT2 inhibitor class of drugs may carry a risk of ketoacidosis. Lawyers say this risk is nowhere to be found on any of the SGLT2 inhibitor drug labels, which means that lawsuits could be filed against negligent manufacturers regarding failure to warn, among other allegations.
In a separate lawsuit, a Louisiana federal court in 2014 ordered Takeda and Eli Lilly to pay a combined $9 billion in punitive damages to a New York state man who claimed that Actos had caused him to develop bladder cancer.
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- Invokana Linked with Cardiovascular Injuries and Kidney Failure lawsuit alleging Invokana side effects including an increased risk of kidney problems and cardiovascular problems
- FDA Warns of Ketoacidosis Linked to SGLT2 inhibitors Canagliflozin, Dapagliflozin, and Empagliflozin
- Saxagliptin marketed as Onglyza and Kombiglyze XR possible increased risk of heart failure
- Victoza Side Effects - Pancreatic and Thyroid Cancer
- Januvia allegedly can cause cancer, pancreatitis and other side effects.
- Byetta allegedly linked to renal kidney failure and acute pancreatitis.
- Actos alleging bladder cancer, heart or kidney damage may have been caused by use of Actos...
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