Abnormal Heart Rhythms Associated With High Doses of Celexa

Washington, DC: The Food and Drug Administration (FDA) has notified healthcare professionals and patients that the antidepressant Celexa (citalopram hydrobromide) should no longer be used at doses greater than 40 mg per day because it can cause abnormal changes in the electrical activity of the heart. Celexa is in a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs).

Changes in the electrical activity of the heart (prolongation of the QT interval of the electrocardiogram [ECG]) can lead to an abnormal heart rhythm (including Torsade de Pointes), which can be fatal. Patients at particular risk for developing prolongation of the QT interval include those with underlying heart conditions and those who are predisposed to low levels of potassium and magnesium in the blood.

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Published on Aug-25-11