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Canadians ingesting Ezetrol may be at risk

 
Merck and Shering-Plough have announced that, based on a study of 720 patients, Vytorin, which combines Zetia (Ezetimibe) and Zocor (Simvastatin), does not reduce the growth of fatty arterial plaque. Rather, patients who took Vytorin had more plaque growth than patients who took only Zocor. In Canada, the drug Zetia is known as Ezetrol and is developed, marketed and sold by Merck Frosst/Schering Pharma GP. The drug Vytorin (a combination of Ezetrol/Zetia and Zocor) is not available in Canada. However, Canadian patients who are prescribed a combination of Ezetrol and Zocor to reduce bad cholesterol may be at risk.

The growth of fatty plaques is correlated to a risk of heart attacks and strokes.

High Blood PressureThe study, known as the ENHANCE trial, showed that the use of Zetia/Ezetrol and Zocor combined was no more effective than simply using a generic version of Zocor alone. The generic version of Zocor is a much less expensive treatment than the combination of Zocor and Zetia/ Ezetrol.

Now, Merck and Shering-Plough are under fire for delaying the release of the ENHANCE trial results. The study was completed in the spring of 2006, but results were only publicized in January 2008. This means that patients who have taken Zetia/Ezetrol have been doing so without knowledge of all the possible risks associated with the drug, while the drugs makers may have known for quite a while about those risks.

A study that shows whether or not patients taking Zetia/Ezetrol are at an increased risk of heart attacks and strokes will not be completed until 2011, almost nine years after Zetia/Ezetrol was approved for use.

The FDA based it's approval of Zetia/Ezetrol on clinical trials conducted on only 3,900 patients over 12 weeks, but even those trials showed that 11 times as many people who took Zetia/ Ezetrol with a statin developed serious health problems, compared with people who only took a statin.

Zetia/Ezetrol is designed to lower a patient's cholesterol, and therefore the risk of cardiovascular events, by blocking the absorption of cholesterol from the intestines.

Ezetrol Heart Attack and Stroke Articles

Ezetrol: Canadian Version of Zetia Questioned
As if the Zetia and Vytorinissue wasn't enough of a frustration on its own, north of the border in Canada the Canadian equivalent of Zetiaâ€"Ezetrolâ€"is proving just as mystifying. At issue: does the cholesterol drug work? Is it harmful? And did the manufacturer, as it was accused of doing in the US, withhold important safety and efficacy information in an effort to protect sales?

Ezetrol: America's Problems are Canada's Problems... and You're Paying for Them
Nowadays, Canada's neighbors include the likes of pharmaceutical giants Merck/Schering Plough; they also include the US federal Food and Drug Administration (FDA). Merck/Schering and its Canadian subsidiary Merck Frosst is the big pharma consortium that manufactures and sells Ezetrol (Zetia in the US market), the anti-cholesterol drug that is now under close scrutiny after ENHANCE test results released in January indicated that it is no better (and quite possibly worse) than cheaper generic statin drugs at reducing arterial plaque and thus users' risk of heart attack and stroke. The FDA is the federal agency that approved Zetia/Ezetrol in October 2002.

Ezetrol Heart Attack and Stroke Legal Help

If you or a loved one has suffered a heart attack or stroke while taking Ezetrol or Zetia, please click the link below to send your complaint to a lawyer to evaluate your claim at no cost or obligation.

Last updated on Feb-27-14


LEGAL ARTICLES AND INTERVIEWS

Ezetrol: Canadian Version of Zetia Questioned
Ezetrol: Canadian Version of Zetia Questioned Toronto, ON: As if the Zetia and Vytorinissue wasn't enough of a frustration on its own, north of the border in Canada the Canadian equivalent of Zetia—Ezetrol—is proving just as mystifying. At issue: does the cholesterol drug work? Is it harmful? And did the manufacturer, as it was accused of doing in the US, withhold important safety and efficacy information in an effort to protect sales [READ MORE]

Ezetrol: America's Problems are Canada's Problems... and You're Paying for Them
Ottawa, ON: Nowadays, Canada's neighbors include the likes of pharmaceutical giants Merck/Schering Plough; they also include the US federal Food and Drug Administration (FDA). Merck/Schering and its Canadian subsidiary Merck Frosst is the big pharma consortium that manufactures and sells Ezetrol (Zetia in the US market), the anti-cholesterol drug that is now under close scrutiny after ENHANCE test results released in January indicated that it is no better (and quite possibly worse) than cheaper generic statin drugs at reducing arterial plaque and thus users' risk of heart attack and stroke. The FDA is the federal agency that approved Zetia/Ezetrol in October 2002 [READ MORE]

Ezetrol: Zetia by Any Other Name...
Toronto, ON: Canadian visitors to LawyersAndSettlements may wonder about all the recent uproar around Zetia, Merck Pharmaceuticals' costly and quite possibly ineffective anti-cholesterol drug, and its offshoot Vytorin, the combination Zetia/simvastatin (Zocor) drug produced jointly by Merck/Schering-Plough. Vytorin, of course, was the subject of the recently released ENHANCE test results. Those results indicated that while Zetia in combination with simvastatin (i.e., Vytorin) did enhance lowering of LDL (bad) cholesterol, the combination drug did no better than simvastatin alone in reducing users' artery plaque, and therefore their risk of heart attack and stroke [READ MORE]

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