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Stevens Johnson Syndrome Linked to Dilantin

The anti-epileptic drug Dilantin has been linked to Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). More than 20 percent of TEN cases, which can develop from SJS, are believed to be caused by SJS Dilantin.


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Dilantin Stevens Johnson Syndrome

Stevens Johnson Syndrome (SJS) is a potentially deadly skin disease, usually caused by a severe allergic reaction to prescribed or over-the-counter (OTC) drugs. SJS has been linked to Dilantin, an anti-epileptic medication used to control seizures by slowing down impulses in the brain.

Dilantin is one of the most commonly prescribed anti-seizure medications in the US and has been marketed by Pfizer and its predecessor companies since 1936. A study that included 15 US burn centers showed that more than 20 percent of TEN cases are believed to be caused by Dilantin, with fatalities in approximately 1 of every 4 cases.

Skin BlisterAlong with SJS, other adverse drug reactions include Toxic Epidermal Necrolysis Symptoms (TEN) and Lyell's Syndrome. SJS is treated by hospitalization but most importantly, the cause must be determined first. If Dilantin is the cause, the medication must be discontinued immediately. If SJS is drug related, the chances of recovery are greatly increased once the drug is recognized. SJS can be fatal in about 15 percent of sufferers.

Allergic drug reactions are a major cause of death in the United States, causing more than 100,000 deaths among patients each year.

Stevens Johnson Syndrome can begin with a fever, sore throat and headache and over a few days or minutes can turn into skin lesions and blisters.

Stevens Johnson Syndrome is characterized by inflammation of the mucous membranes of the mouth, throat, eyes, genital tract and intestinal tract. Ulcers inside the mouth are the most common, irritation to the throat, tongue, gums, and lips. Affected individuals may also have skin lesions, blisters and bleeding in the lips, eyes, mouth, nasal passage and genital areas.

As Stevens Johnson Syndrome evolves, the skin literally sloughs off in sheets. Patients are typically treated in a hospital's burn unit. If the skin lesions become infected, or the patient develops lesions in the lungs, it can cause death.

Possible side effects of Dilantin can include:
  • Liver Damage
  • Rash
  • Hallucinations
  • Irregular Heartbeat
  • Decreased Blood Pressure
  • Increased Blood Sugar
  • Birth Defects

Dilantin SJS Lawsuits

In May 2006, the parents of a nine-year-old girl who was prescribed Dilantin and later died from TEN filed a wrongful death lawsuit against Pfizer and McNeil Consumer & Specialty Pharmaceuticals. The lawsuit claimed that Pfizer had not bothered warning doctors and patients in the US of a higher risk for developing Dilantin Hypersensitivity Syndrome which can include TEN, and that “Pfizer's label does not advise clinicians that a drug-company sponsored survey of seizure clinicians concluded that Dilantin should virtually never be used as a first line anti-seizure drug for children”.

Following a hearing before a New York State Supreme Court Judge in October 2010, Pfizer will pay a $3.78 million settlement to the family.

Dilantin SJS and TEN Class Action Lawsuit

In January 2011 a class action lawsuit was filed against Dilantin manufacturers Pfizer, Parke Davis and Warner Lambert, claiming that Dilantin caused the plaintiffs or their deceased relatives to develop SJS or TEN. The lawsuit alleges that, “Post-marketing databases confirm that serious skin reactions have been reported in patients receiving Dilantin drug products…including the US-FDA Adverse Event Reporting System.”

The lawsuit further alleges that the manufacturers knew of the drugs' dangers, but failed to adequately warn, and that Pfizer (in its submission on Bextra to Health Canada) said that drugs containing Dilantin substantially increased the risk of adverse skin reactions more so than other drugs on the market.

The plaintiffs are claiming strict products liability, negligence, failure to warn, negligence in bringing Dilantin to market, negligent misrepresentation, misrepresentation by omission, negligence per se, fraud and misrepresentation, fraud by concealment, violation of the Illinois Consumer Fraud Act and wrongful death.

Generic Dilantin SJS Lawsuit

In March 2011, a lawsuit was filed against the generic makers of Dilantin-- Sun Pharmaceuticals Industries, Caraco Pharmaceutical Laboratories, Hospira, UDL Laboratories and Mylan Pharmaceuticals and their subsidiaries--claiming SJS and TEN was caused by taking the generic epilepsy drug Dilantin.

Charles Henderson of Georgia took both generic Dilantin and generic fosphenytoin. Dilantin (phenytoin). The lawsuit notes that there have been more than 1,000 SJS cases from Dilantin and at least 139 deaths from SJS. Although the FDA acknowledged Dilantin’s link to SJS and TENS in 2008, Henderson says there should have been more warning about the risk of getting SJS.

Dilantin SJS Legal Help

If you or a loved one has suffered from Stevens Johnson Syndrome after taking Dilantin, please click the link below to send your complaint to a lawyer to evaluate your claim at no cost or obligation.

Last updated on Jul-20-11


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